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Klar-501: A Study on Tyrosinase Inhibition and Melanogenesis Suppression in Post-Acne Hyperpigmentation
A single-subject (N-of-1) pilot study evaluating a topical 5% niacinamide compound for reducing post-inflammatory hyperpigmentation (PIH) following acne, via inhibition of melanosome transfer to keratinocytes. Conducted over an 8-week application period with standardized photographic documentation, weekly severity scoring, and tolerability monitoring.
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SAL-200: Comedolytic Efficacy and Follicular Exfoliation in Active Acne Lesions
A single-subject (N-of-1) pilot study evaluating a topical 2% salicylic acid serum for its comedolytic effect on active acne — assessing reduction in blackhead/whitehead count, pore congestion, and active lesion number. Conducted over an 8-week application period with standardized photographic documentation, weekly lesion counts, and tolerability monitoring.
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NIA-501: Sebum Regulation and Erythema Reduction in Blemish-Prone Skin
A single-subject (N-of-1) pilot study evaluating a topical 5% niacinamide/zinc PCA serum for its effect on sebum production and post-blemish redness in blemish-prone skin. Conducted over an 8-week application period with standardized photographic documentation, weekly sebum/shine and erythema severity scoring, and tolerability monitoring.
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EZC-01: Transepidermal Water Loss Reduction in Compromised Skin Barrier Function
A single-subject (N-of-1) pilot study evaluating a topical ceramide/colloidal oatmeal barrier-repair cream for its effect on transepidermal water loss (TEWL) and hydration retention in compromised, eczema-prone skin. Conducted over an 8-week application period with standardized photographic documentation, weekly hydration/flaking severity scoring, and tolerability monitoring.
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PSL-01: Keratolytic Activity and Plaque Scale Reduction in Hyperkeratotic Skin
A single-subject (N-of-1) pilot study evaluating a topical willow bark extract/allantoin lotion for its keratolytic effect on plaque thickness and scale buildup in hyperkeratotic, psoriasis-prone skin. Conducted over an 8-week application period with standardized photographic documentation, weekly plaque severity scoring, and tolerability monitoring.
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ROF-01: Vascular Reactivity and Erythema Suppression in Reactive Skin
A single-subject (N-of-1) pilot study evaluating a topical azelaic acid/zinc oxide mineral fluid for its effect on facial flushing, vascular reactivity, and persistent erythema in rosacea-prone, reactive skin. Conducted over an 8-week application period with standardized photographic documentation, weekly redness/flushing severity scoring, and tolerability monitoring.
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ROF-01: Vascular Reactivity and Erythema Suppression in Reactive Skin
A single-subject (N-of-1) pilot study evaluating a topical azelaic acid/zinc oxide mineral fluid for its effect on facial flushing, vascular reactivity, and persistent erythema in rosacea-prone, reactive skin. Conducted over an 8-week application period with standardized photographic documentation, weekly redness/flushing severity scoring, and tolerability monitoring.
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